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A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.

Mitochondrial DNA (mtDNA) encodes respiratory complex subunits essential to almost all eukaryotes; hence respiratory competence requires faithful duplication of this molecule. However, the mechanism(s) of its synthesis remain hotly debated. Here we have developed Caenorhabditis elegans as a convenie...

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Detalhes bibliográficos
Main Authors: Samantha C Lewis, Priit Joers, Smaranda Willcox, Jack D Griffith, Howard T Jacobs, Bradley C Hyman
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-02-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC4334201?pdf=render
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