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Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a...

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主要な著者: Joanne Marie M. Del Rosario, Matthew Smith, Kam Zaki, Paul Risley, Nigel Temperton, Othmar G. Engelhardt, Mary Collins, Yasuhiro Takeuchi, Simon E. Hufton
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2020-05-01
シリーズ:Frontiers in Immunology
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オンライン・アクセス:https://www.frontiersin.org/article/10.3389/fimmu.2020.00627/full
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