Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a...

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Main Authors: Joanne Marie M. Del Rosario, Matthew Smith, Kam Zaki, Paul Risley, Nigel Temperton, Othmar G. Engelhardt, Mary Collins, Yasuhiro Takeuchi, Simon E. Hufton
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Assuntos:
influenza
vaccine
adeno associated viral vectors
immunoprophylaxis
immunotherapy
nanobody
Acceso en liña:https://www.frontiersin.org/article/10.3389/fimmu.2020.00627/full
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