Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a...

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Bibliographic Details
Main Authors: Joanne Marie M. Del Rosario, Matthew Smith, Kam Zaki, Paul Risley, Nigel Temperton, Othmar G. Engelhardt, Mary Collins, Yasuhiro Takeuchi, Simon E. Hufton
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
influenza
vaccine
adeno associated viral vectors
immunoprophylaxis
immunotherapy
nanobody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00627/full
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