Direct Binding and Regulation by Fur and HapR of the Intermediate Regulator and Virulence Factor Genes Within the ToxR Virulence Regulon in Vibrio cholerae

Cholera toxin (CT) and toxin coregulated pilus (TCP, TcpA is the major subunit) are two major virulence factors of Vibrio cholerae, both of which play critical roles in developing severe diarrhea in human. Expression of CT and TCP is under the tight control of the regulatory cascade known as the Tox...

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Bibliographische Detailangaben
Hauptverfasser: He Gao, Jingyun Zhang, Jing Lou, Jie Li, Qin Qin, Qiannan Shi, Yiquan Zhang, Biao Kan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-04-01
Schriftenreihe:Frontiers in Microbiology
Schlagworte:
Vibrio cholerae
toxin coregulated pilus
cholera toxin
HapR
Fur
Online Zugang:https://www.frontiersin.org/article/10.3389/fmicb.2020.00709/full
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