Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy

<p>Abstract</p> <p>Background</p> <p>Combination of oncolytic vaccinia virus therapy with conventional chemotherapy has shown promise for tumor therapy. However, side effects of chemotherapy including thrombocytopenia, still remain problematic.</p> <p>Method...

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Detalhes bibliográficos
Main Authors: Sturm Julia B, Hess Michael, Weibel Stephanie, Chen Nanhai G, Yu Yong A, Zhang Qian, Donat Ulrike, Reiss Cora, Gambaryan Stepan, Krohne Georg, Stritzker Jochen, Szalay Aladar A
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-01-01
Colecção:Journal of Translational Medicine
Assuntos:
vaccinia virus
cancer
cytokine
hyper-IL-6
oncolysis
chemotherapy
Acesso em linha:http://www.translational-medicine.com/content/10/1/9
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