Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways

Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of function in the translation machinery components results in rare ribosomopathy disorders, such as Diamond...

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Bibliographic Details
Main Authors: Agustian Surya, Elif Sarinay-Cenik
Format: Artigo
Language:Inglês
Published: The Royal Society 2022-04-01
Series:Open Biology
Subjects:
ribosomes
ribosomopathy
haploinsufficiency
cell competition
cell non-autonomous
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210308
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