Peroxiredoxin 6 mediates acetaminophen-induced hepatocyte death through JNK activation

Acetaminophen (APAP) is one of the most frequently used drugs; however, its overdose leads to acute liver injury. Recently, studies have reported that the adduction of peroxiredoxin 6 (PRDX6), a member of the PRDX family of antioxidant enzymes, is associated with liver diseases. However, the role of...

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Detalhes bibliográficos
Main Authors: Dong Hun Lee, Young Suk Jung, Jaesuk Yun, Sang Bae Han, Yoon Seok Roh, Min Jong Song, Jin Tae Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-05-01
Colecção:Redox Biology
Assuntos:
Peroxiredoxin 6
Acetaminophen
Calcium-independent phospholipase A2
Lysophosphatidylcholine
c-Jun N-Terminal kinases
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231719314855
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