Clinical and positron emission tomography responses to long-term high-dose interferon-α treatment among patients with Erdheim–Chester disease

Abstract Background Erdheim–Chester disease (ECD) is a rare multi-systemic form of histiocytosis. Treatment with BRAF inhibitors has markedly improved outcomes of ECD; however, this targeted therapy is expensive (estimated annual cost is $50,000). Since estimated annual cost of interferon-α (IFN-α)...

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Bibliographic Details
Main Authors: Xin-xin Cao, Na Niu, Jian Sun, Hao Cai, Feng-dan Wang, Yi-ning Wang, Ming-hui Duan, Dao-bin Zhou, Jian Li
Format: Artigo
Language:Inglês
Published: BMC 2019-01-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Erdheim–Chester disease
BRAF V600E mutation
Interferon-α
Positron-emission tomography
Online Access:http://link.springer.com/article/10.1186/s13023-018-0988-y
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