Methodological Issues in the Clinical Validation of Biomarkers for Alzheimer’s Disease: The Paradigmatic Example of CSF

The use of biomarkers is profoundly transforming medical research and practice. Their adoption has triggered major advancements in the field of Alzheimer’s disease (AD) over the past years. For instance, the analysis of the cerebrospinal fluid (CSF) and neuroimaging changes indicative of neuronal lo...

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Detalhes bibliográficos
Main Authors: Marco Canevelli, Ilaria Bacigalupo, Giuseppe Gervasi, Eleonora Lacorte, Marco Massari, Flavia Mayer, Nicola Vanacore, Matteo Cesari
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-10-01
Colecção:Frontiers in Aging Neuroscience
Assuntos:
biomarkers
Alzheimer’s disease
validation
diagnostic research
epidemiology
mild cognitive impairment
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnagi.2019.00282/full
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