Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor-β1 in streptozotocin-induced diabetic rat model

Objective(s):Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (TGF-β). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFβ1 modula...

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Detalhes bibliográficos
Main Authors: Maryam Foroutan Jazi, Alireza Biglari, Saeideh Mazloomzadeh, Paul Kingston, Ali Ramazani, Javad Tavkoli Bazzaz, Mehdi Eskandari
Formato: Artigo
Idioma:Inglês
Publicado em: Mashhad University of Medical Sciences 2016-03-01
Colecção:Iranian Journal of Basic Medical Sciences
Assuntos:
Diabetic rats
Diabetic nephropathy
Fibromodulin
Gene therapy
TGF-β1
Acesso em linha:http://ijbms.mums.ac.ir/article_6645_26d8966bc777498497784359b795d8ff.pdf
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