Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice

Nuciferine (Nuci), the main aporphine alkaloid component in lotus leaf, was reported to reduce lipid accumulation in vitro. Herein we investigated whether Nuci prevents obesity in high fat diet (HFD)-fed mice and the underlying mechanism in liver/HepG2 hepatocytes and epididymal white adipose tissue...

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Main Authors: Hanyuan Xu, Xiaorui Lyu, Xiaonan Guo, Hongbo Yang, Lian Duan, Huijuan Zhu, Hui Pan, Fengying Gong, Linjie Wang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:Nutrients
Assuntos:
Nuciferine (Nuci)
AMP-activated protein kinase (AMPK)
fatty acid synthase (FAS)
hormone sensitive lipase (HSL)
obesity
hepatic steatosis
Acceso en liña:https://www.mdpi.com/2072-6643/14/9/1898
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