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Sulfated alginate oligosaccharide exerts antitumor activity and autophagy induction by inactivating MEK1/ERK/mTOR signaling in a KSR1-dependent manner in osteosarcoma

Abstract Alginate oligosaccharide (AOS) has the function to inhibit tumor progression and the sulfated modification can enhance the antitumor activity. To date, the function and mechanism of sulfated AOS (AOS-SO4) in tumors remain largely elusive. We prepared AOS by the enzymatic degradation of algi...

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Detalhes bibliográficos
Main Authors: Zhen Pan, Xiao-juan Wei, Shi-jie Li, Hua Guo, Zhao-hui Li, Ke-ke Zhang, Qian-qian Lyu, Wei-zhi Liu, Qing-cheng Yang, Dong-dong Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2022-04-01
Colecção:Oncogenesis
Acesso em linha:https://doi.org/10.1038/s41389-022-00390-x
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