MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma

Abstract Background MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids. The purpose of this study was to investigate the functional significan...

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Detalhes bibliográficos
Main Authors: Eden R. Cardozo, Rosemary Foster, Anatte E. Karmon, Amy E. Lee, Leah W. Gatune, Bo R. Rueda, Aaron K. Styer
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-05-01
Colecção:Reproductive Biology and Endocrinology
Assuntos:
Fibroids
Leiomyoma
miR-21
Extracellular matrix
TGF-β
Acesso em linha:http://link.springer.com/article/10.1186/s12958-018-0364-8
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