Integrated Quantitative Proteomics and Metabolome Profiling Reveal MSMEG_6171 Overexpression Perturbing Lipid Metabolism of Mycobacterium smegmatis Leading to Increased Vancomycin Resistance

In recent years, the treatment of tuberculosis is once again facing a severe situation because the existing antituberculosis drugs have become weaker and weaker with the emergence of drug-resistant Mycobacterium tuberculosis (Mtb). The studies of cell division and cell cycle-related factors in Mtb a...

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Hlavní autoři: Zhuhua Wu, Wenjing Wei, Ying Zhou, Huixin Guo, Jiao Zhao, Qinghua Liao, Liang Chen, Xiaoli Zhang, Lin Zhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-07-01
Edice:Frontiers in Microbiology
Témata:
MSMEG_6171
lipid metabolism
Mycobacterium smegmatis
drug resistance
multi-omics
On-line přístup:https://www.frontiersin.org/article/10.3389/fmicb.2020.01572/full
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