Interleukin-6 Elevation Is a Key Pathogenic Factor Underlying COVID-19-Associated Heart Rate-Corrected QT Interval Prolongation

BackgroundHeart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. Recent evidence suggests that the exaggerated host immune-inflammatory response characterizing the disease, specifically interl...

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Detalhes bibliográficos
Main Authors: Pietro Enea Lazzerini, Riccardo Accioli, Maurizio Acampa, Wen-Hui Zhang, Decoroso Verrengia, Alessandra Cartocci, Maria Romana Bacarelli, Xiaofeng Xin, Viola Salvini, Ke-Su Chen, Fabio Salvadori, Antonio D’errico, Stefania Bisogno, Gabriele Cevenini, Tommaso Marzotti, Matteo Capecchi, Franco Laghi-Pasini, Long Chen, Pier Leopoldo Capecchi, Mohamed Boutjdir
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Cardiovascular Medicine
Assuntos:
QTc interval
systemic inflammation
interleukin-6
guinea pig model
ventricular electrical remodelling
action potential duration
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2022.893681/full
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