Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer’s Disease

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising for the treatment of Alzheimer’s disease (AD). However, their low rate of migration and survival in the brain limit their clinical applicability. This study is designed to improve the therapeutic potential of hUC-MSCs by pr...

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Detalhes bibliográficos
Main Authors: Xinxin Wang, Junwei Wu, Shanshan Ma, Ya Xie, Hongtao Liu, Minghao Yao, Yanting Zhang, Greta Luyuan Yang, Bo Yang, Ruixia Guo, Fangxia Guan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-03-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
Alzheimer’s disease
human umbilical cord-derived mesenchymal stem cells
resveratrol
MAPK
neuroinflammation
Acesso em linha:https://www.frontiersin.org/article/10.3389/fncel.2020.00062/full
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