Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently, a VHH is engrafted onto constant region CH1...

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Detalhes bibliográficos
Main Authors: Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
Colecção:mAbs
Assuntos:
Antibody engineering
bispecific antibody
camelid
IgG-like
nanobody
single-domain antibody
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2020.1812210
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