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Inactivation of P2YR12 contributes to isoflurane-induced neuronal injury by altering TLR-4/BDNF/TNF-α
The present investigation evaluated the effect of inhibiting the P2Y12 gene on anaesthetic-induced neuronal injury in a rat model. Neuronal injury was induced by exposing the animals for 6 h to 30% oxygen containing 0.75% isoflurane and 1.2 mg/kg prasugrel (a P2Y12 inhibitor) p.o. for 14 days. Cogni...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Termedia Publishing House
2019-06-01
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| Colecção: | Folia Neuropathologica |
| Assuntos: | |
| Acesso em linha: | https://www.termedia.pl/Inactivation-of-P2YR12-contributes-to-isoflurane-induced-neuronal-injury-by-altering-TLR-4-BDNF-TNF-,20,37042,1,1.html |
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