A Cosine Similarity-Based Method to Infer Variability of Chromatin Accessibility at the Single-Cell Level

Cellular identity between generations of developing cells is propagated through the epigenome particularly via the accessible parts of the chromatin. It is now possible to measure chromatin accessibility at single-cell resolution using single-cell assay for transposase accessible chromatin (scATAC-s...

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Main Authors: Stanley Cai, Georgios K. Georgakilas, John L. Johnson, Golnaz Vahedi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-08-01
Colecção:Frontiers in Genetics
Assuntos:
single-cell
chromatin
ATAC-seq
multidimensional scaling
variation
code:R
Acesso em linha:https://www.frontiersin.org/article/10.3389/fgene.2018.00319/full
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