m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

Abstract LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC tissues and corresponding normal tissues from 48 patients and identified LHPP as a d...

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Main Authors: Jian-Xian Lin, Ning-Zi Lian, You-Xin Gao, Qiao-Ling Zheng, Ying-Hong Yang, Yu-Bin Ma, Zhi-Song Xiu, Qing-Zhu Qiu, Hua-Gen Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Jia-Bin Wang, Chang-Ming Huang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04859-w
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