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Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes

Congenital heart defects (CHDs) occur with such a frequency that they constitute a significant cause of morbidity and mortality in both children and adults. A significant portion of CHDs can be attributed to aberrant development of the cardiac outflow tract (OFT), and of one of its cellular progenit...

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Главные авторы: Joshua W. Vincentz, David E. Clouthier, Anthony B. Firulli
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-04-01
Серии:Journal of Cardiovascular Development and Disease
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Online-ссылка:https://www.mdpi.com/2308-3425/7/2/13
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