Identification of Single Amino Acid Changes in the Rift Valley Fever Virus Polymerase Core Domain Contributing to Virus Attenuation In Vivo

Rift Valley fever (RVF) is an arboviral zoonotic disease affecting many African countries with the potential to spread to other geographical areas. RVF affects sheep, goats, cattle and camels, causing a high rate of abortions and death of newborn lambs. Also, humans can be infected, developing a usu...

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Main Authors: Belén Borrego, Sandra Moreno, Álvaro López-Valiñas, Nuria de la Losa, Friedemann Weber, José Ignacio Núñez, Alejandro Brun
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-04-01
Serija:Frontiers in Cellular and Infection Microbiology
Teme:
RVFV
viral polymerase
attenuation
live vaccines
reverse genetics
mutagenic drugs
Online dostop:https://www.frontiersin.org/articles/10.3389/fcimb.2022.875539/full
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