Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [<sup>18</sup>F]FAZA PET <i>In Vivo</i>

Tumors lack a well-regulated vascular supply of O<sub>2</sub> and often fail to balance O<sub>2</sub> supply and demand. Net O<sub>2</sub> tension within many tumors may not only depend on O<sub>2</sub> delivery but also depend strongly on O<sub>...

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Detaylı Bibliyografya
Asıl Yazarlar: Seth T. Gammon, Federica Pisaneschi, Madhavi L. Bandi, Melinda G. Smith, Yuting Sun, Yi Rao, Florian Muller, Franklin Wong, John De Groot, Jeffrey Ackroyd, Osama Mawlawi, Michael A. Davies, Y.N. Vashisht Gopal, M. Emilia Di Francesco, Joseph R. Marszalek, Mark Dewhirst, David Piwnica-Worms
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2019-11-01
Seri Bilgileri:Cells
Konular:
hypoxia
[18f]faza
pet
iacs-010759
mitochondrial complex i
metabolism
pharmacodynamics
oxidative phosphorylation
collateral lethality
Online Erişim:https://www.mdpi.com/2073-4409/8/12/1487
Etiketler: Etiketle
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