Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material

Abstract Background Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for testing, genetic markers are rapidly expanding. Simultaneous detection of predictive markers, including mutations, gene amplific...

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Main Authors: Elisabeth M. P. Steeghs, Leonie I. Kroeze, Bastiaan B. J. Tops, Leon C. van Kempen, Arja ter Elst, Annemiek W. M. Kastner-van Raaij, Sandra J. B. Hendriks-Cornelissen, Mandy J. W. Hermsen, Erik A. M. Jansen, Petra M. Nederlof, Ed Schuuring, Marjolijn J. L. Ligtenberg, Astrid Eijkelenboom
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2020-04-01
Sraith:BMC Cancer
Ábhair:
Predictive analysis
Next-generation sequencing
Mutation
Gene amplification
Microsatellite instability
FFPE
Rochtain Ar Líne:http://link.springer.com/article/10.1186/s12885-020-06785-6
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