Single-Cell Characterization of Hepatic CD8+ T Cells in a Murine Model of Primary Biliary Cholangitis

Primary biliary cholangitis (PBC), an organ-specific autoimmune disease, is characterized by injury to small bile ducts, inflammatory cell infiltrates within the liver, progressive cholestasis, and in some cases, cirrhosis with unclear pathogenesis. We aimed to clarify the importance role of hepatic...

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Autores principales: Yichen Han, Zhen-Hua Bian, Si-Yu Yang, Cheng-Bo Wang, Liang Li, Yan-Qing Yang, Aftab A. Ansari, M. Eric Gershwin, Xiaofeng Zeng, Zhe-Xiong Lian, Zhi-Bin Zhao
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2022-04-01
Colección:Frontiers in Immunology
Materias:
primary biliary cholangitis
CD8+ T cells
single-cell sequencing
TCR repertoire
liver
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2022.860311/full
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