A Neural Network Framework for Predicting the Tissue-of-Origin of 15 Common Cancer Types Based on RNA-Seq Data

Sequencing-based identification of tumor tissue-of-origin (TOO) is critical for patients with cancer of unknown primary lesions. Even if the TOO of a tumor can be diagnosed by clinicopathological observation, reevaluations by computational methods can help avoid misdiagnosis. In this study, we devel...

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Detalhes bibliográficos
Main Authors: Binsheng He, Yanxiang Zhang, Zhen Zhou, Bo Wang, Yuebin Liang, Jidong Lang, Huixin Lin, Pingping Bing, Lan Yu, Dejun Sun, Huaiqing Luo, Jialiang Yang, Geng Tian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Bioengineering and Biotechnology
Assuntos:
cancer of unknown primary
tissue-of-origin
neural network
RNA sequencing
the Pearson correlation
Acesso em linha:https://www.frontiersin.org/article/10.3389/fbioe.2020.00737/full
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