Inhibition of Single Routes of Intracellular Signaling is Not Sufficient to Neutralize the Biphasic Disturbance of a Retinal Endothelial Cell Barrier Induced by VEGF-A165

Background/Aims: Hallmark of diabetic macular edema is the enhanced permeability of retinal endothelial cells (REC) induced by vascular endothelial growth factor (VEGF-A165), which acts through activating specific receptors. To improve the predictability of inhibitors' potentials to block harmf...

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Detalhes bibliográficos
Main Authors: Heidrun L. Deissler, Gerhard K. Lang, Gabriele E. Lang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2017-07-01
Colecção:Cellular Physiology and Biochemistry
Assuntos:
MEK
Permeability
Cell index measurement
Inhibitors
Tight junctions
Retinal endothelial cells
VEGF-A
VEGF receptor
Protein kinase
Protein kinase C
Acesso em linha:http://www.karger.com/Article/FullText/479213
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