Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells

Almost 50 million people in the world are affected by dementia; the most prevalent form of which is Alzheimer’s disease (AD). Although aging is considered to be the main risk factor for AD, growing evidence from epidemiological studies suggests that type 2 diabetes mellitus (T2DM) increases the risk...

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Main Authors: Shreyasi Chatterjee, Suren. S. Ambegaokar, George R. Jackson, Amritpal Mudher
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-08-01
Serier:Frontiers in Neuroscience
Fag:
Alzheimer’s disease
type 2 diabetes
tau aggregation
autophagy
tau hyper-phosphorylation
Online adgang:https://www.frontiersin.org/article/10.3389/fnins.2019.00801/full
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