Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic acid decarboxylase 65, that is CpG hyper-meth...

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Detalhes bibliográficos
Main Authors: David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-03-01
Colecção:Biomedicines
Assuntos:
diabetes
immunotherapy
hyperglycemia
dna immunotherapy
nod mouse
type 1 diabetes
antigen-specific
dna plasmids
adi-100
monotherapy
apoptosis
bax
t cells
sgad55
pre-diabetic mouse
Acesso em linha:https://www.mdpi.com/2227-9059/8/3/53
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