MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer

Background/Aims: Early metastasis plays a pivotal role in tumor-caused death in gallbladder cancer (GBC) patients. Increasing evidence suggest that miR-143-5p is an active player involved in cancer metastasis and a potential therapeutic target. However, its role in the development of GBC cells remai...

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Detalhes bibliográficos
Main Authors: Min He, Ming Zhan, Wei Chen, Sunwang Xu, Manmei Long, Hui Shen, Yongheng Shi, Qiang Liu, Man Mohan, Jian Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Colecção:Cellular Physiology and Biochemistry
Assuntos:
Gallbladder cancer
miR-143-5p
HIF-1α
Epithelial-mesenchymal transition
Metastasis
Acesso em linha:http://www.karger.com/Article/FullText/479903
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