Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer

Several recent studies suggest that cancer stem cells (CSCs) are involved in intrinsic resistance to cancer treatment. Maintenance of quiescence is crucial for establishing resistance of CSCs to cancer therapeutics. F-box/WD repeat-containing protein 7 (FBXW7) is a ubiquitin ligase that regulates qu...

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Main Authors: Moulid Hidayat, Yoichiro Mitsuishi, Fumiyuki Takahashi, Ken Tajima, Toshifumi Yae, Katsumi Miyahara, Daisuke Hayakawa, Wira Winardi, Hiroaki Ihara, Yoshika Koinuma, Aditya Wirawan, Fariz Nurwidya, Motoyasu Kato, Isao Kobayashi, Shinichi Sasaki, Kazuya Takamochi, Takuo Hayashi, Yoshiyuki Suehara, Mariko Moriyama, Hiroyuki Moriyama, Sonoko Habu, Kazuhisa Takahashi
Formato: Artigo
Idioma:Inglês
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2019-05-01
Series:Bosnian Journal of Basic Medical Sciences
Assuntos:
FBXW7
quiescence
cancer stem cells
gefitinib resistance
NSCLC
Acceso en liña:http://www.bjbms.org/ojs/index.php/bjbms/article/view/4227
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