Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling

Abstract Background We previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency (CIRCI) and mortality in rats with traumatic brain injury (TBI), whereas low-dose hydrocortisone but not methylprednisolone exerted protective ef...

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Detalhes bibliográficos
Main Authors: Bin Zhang, Miao Bai, Xiaojian Xu, Mengshi Yang, Fei Niu, Fei Gao, Baiyun Liu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-10-01
Colecção:Journal of Neuroinflammation
Assuntos:
Glucocorticoids
Corticosteroid receptor balance
Critical illness-related corticosteroid insufficiency
Apoptosis
Traumatic brain injury
Acesso em linha:http://link.springer.com/article/10.1186/s12974-020-02000-2
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