Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Abstract Background Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients and make epigenetic ins...

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Detalhes bibliográficos
Main Authors: Jie-Xue Pan, Ya-Jing Tan, Fang-Fang Wang, Ning-Ning Hou, Yu-Qian Xiang, Jun-Yu Zhang, Ye Liu, Fan Qu, Qing Meng, Jian Xu, Jian-Zhong Sheng, He-Feng Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-01-01
Colecção:Clinical Epigenetics
Assuntos:
Polycystic ovary syndrome
RNA-seq
Methylation
Hyperandrogenism
Synthesis of lipid and steroid
Acesso em linha:http://link.springer.com/article/10.1186/s13148-018-0442-y
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