Description of Genetic Variants in BRCA Genes in Mexican Patients with Ovarian Cancer: A First Step towards Implementing Personalized Medicine

Gynecologic cancers are among the leading causes of death worldwide, ovarian cancer being the one with the highest mortality rate. Olaparib is a targeted therapy used in patients presenting mutations in BRCA1 and BRCA2 genes. The aim of this study was to describe BRCA1 and BRCA2 gene variants in Mex...

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Main Authors: Jesus Rolando Delgado-Balderas, Maria Lourdes Garza-Rodriguez, Gabriela Sofia Gomez-Macias, Alvaro Barboza-Quintana, Oralia Barboza-Quintana, Ricardo M. Cerda-Flores, Ivett Miranda-Maldonado, Hugo Mauricio Vazquez-Garcia, Lezmes Dionicio Valdez-Chapa, Mauro Antonio-Macedo, Michael Dean, Hugo A. Barrera-Saldaña
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-07-01
Colecção:Genes
Assuntos:
BRCA
ovarian cancer
personalized therapy
sequencing
Acesso em linha:http://www.mdpi.com/2073-4425/9/7/349
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