Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

Recombinant strains of hepatitis E virus (HEV) with insertions of human genomic fragments or HEV sequence duplications in the sequence encoding the polyproline region (PPR) were previously described in chronically infected patients. Such genomic rearrangements confer a replicative advantage in vitro...

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Bibliographic Details
Main Authors: Sébastien Lhomme, Florence Nicot, Nicolas Jeanne, Chloé Dimeglio, Alain Roulet, Caroline Lefebvre, Romain Carcenac, Maxime Manno, Martine Dubois, Jean-Marie Peron, Laurent Alric, Nassim Kamar, Florence Abravanel, Jacques Izopet
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
hepatitis E virus
polyproline region
genomic rearrangement
virus-host recombinant variants
virus-virus recombinant variants
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00001/full
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