Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of FcγRI and reduced RANKL signalling

Abstract Objectives Bone destruction is a remarkable feature of inflammatory arthritis. It remains unknown why arthritis associated with the systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE) does not result in erosion and destruction. We aimed to determine the role of aut...

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Detalhes bibliográficos
Main Authors: Wei Qiao, Huimin Ding, Yuyue Zuo, Lijuan Jiang, Jiayuan Zhou, Xiaoxiao Han, Likai Yu, Rong Du, Christian M Hedrich, Guo‐Min Deng
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-01-01
Colecção:Clinical & Translational Immunology
Assuntos:
arthritis
bone destruction
Fcγ receptor
IgG
osteoclastogenesis
systemic lupus erythematosus
Acesso em linha:https://doi.org/10.1002/cti2.1174
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