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Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury

Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen′s method in rats....

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Detalhes bibliográficos
Main Authors:	Jian-long Wang, Qing-shan Zhang, Kai-di Zhu, Jian-feng Sun, Ze-peng Zhang, Jian-wen Sun, Ke-xiang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2015-01-01
Colecção:	Neural Regeneration Research
Assuntos:	microtubule axon kinesin-5 Eg5 regeneration monastrol molecular motor protein aging neurodegenerative disorders telomere shortening MSCs cellular therapy traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion blood brain barrier phage display peptide library nanocarrier targeting Schwann cells neurite outgrowth neuromuscular junction (NMJ) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression nerve regeneration bone marrow mesenchymal stem cells cerebral ischemia tail vein injection middle cerebral artery occlusion cell therapy neuroprotection brain injury neuroimaging ferumoxytol superparamagnetic iron oxide particles human adipose-derived stem cells intracerebral injection magnetic resonance imaging enhanced susceptibility-weighted angiography image modified neurological severity scores rats Prussian blue staining neural regeneration non-invasive brain stimulation transcranial magnetic stimulation neurotrophic factor brain-derived neurotrophic factor neuroplasticity hippocampus cognitive function curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca 2+ synaptosome NSFC grants hydrogen sulfide cerebral ischemia/reperfusion injury P2X 7 receptor 2 3 5-triphenyl-2H-tetrazolium chloride staining animal model protection sodium hydrosulfide immunofluorescence NSFC grant γ-aminobutyric acid glial fibrillary acidic protein glutamic acid decarboxylase neurotoxicity weaning organ index cerebrum cortex glutamate p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting spinal cord injury rapamycin Wnt/β-catenin signaling pathway apoptosis caspase-3 loss of neurons hydrogen-rich saline reactive oxygen species physiological saline oxidative stress Basso Beattie and Bresnahan score malondialdehyde superoxide dismutase calcitonin gene-related peptide
Acesso em linha:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=958;epage=964;aulast=Wang
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Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury

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