Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

Alzheimer’s disease (AD), the most common form of dementia in adults, is a progressive neurodegenerative disorder of the brain characterized by loss of memory and steady deterioration of cognition. Here, a series of symmetrical molecules containing biphenyl/bibenzyl scaffolds (12–36) were designed,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dong-mei Wang, Bo Feng, Hui Fu, Ai-lin Liu, Lin Wang, Guan-hua Du, Song Wu
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2017-01-01
Colección:Molecules
Materias:
Alzheimer’s disease
biphenyl/bibenzyl derivatives
acetylcholinesterase inhibitors
butyrylcholinesterase inhibitors
molecular docking
Acceso en línea:http://www.mdpi.com/1420-3049/22/1/172
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares