Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

Alzheimer’s disease (AD), the most common form of dementia in adults, is a progressive neurodegenerative disorder of the brain characterized by loss of memory and steady deterioration of cognition. Here, a series of symmetrical molecules containing biphenyl/bibenzyl scaffolds (12–36) were designed,...

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Bibliographic Details
Main Authors: Dong-mei Wang, Bo Feng, Hui Fu, Ai-lin Liu, Lin Wang, Guan-hua Du, Song Wu
Format: Artigo
Language:Inglês
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
Alzheimer’s disease
biphenyl/bibenzyl derivatives
acetylcholinesterase inhibitors
butyrylcholinesterase inhibitors
molecular docking
Online Access:http://www.mdpi.com/1420-3049/22/1/172
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