Metronomic Celecoxib Therapy in Clinically Available Dosage Ablates Hepatocellular Carcinoma via Suppressing Cell Invasion, Growth, and Stemness in Pre-Clinical Models

ObjectiveTo investigate the anti-carcinogenic effect of metronomic Celecoxib (i.e., frequent administration in clinically available doses) against hepatocellular carcinoma (HCC) in the perspective of metastasis, spontaneous hepatocarcinogenesis, cancer invasion, proliferation, and stemness in vivo a...

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Detalhes bibliográficos
Main Authors: Chun-Chieh Yeh, Pei-Ying Liao, Sudhir Pandey, Su-Yung Yung, Hsueh-Chou Lai, Long-Bin Jeng, Wei-Chun Chang, Wen-Lung Ma
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-10-01
Colecção:Frontiers in Oncology
Assuntos:
NSAID (nonsteroidal anti-inflammatory drug)
Celecoxib
hepatocellular carcinoma (HCC)
NFκB
metronomic
chemoprevention
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2020.572861/full
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