A multi-labeled tree dissimilarity measure for comparing “clonal trees” of tumor progression

Abstract We introduce a new dissimilarity measure between a pair of “clonal trees”, each representing the progression and mutational heterogeneity of a tumor sample, constructed by the use of single cell or bulk high throughput sequencing data. In a clonal tree, each vertex represents a specific tum...

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Bibliographic Details
Main Authors: Nikolai Karpov, Salem Malikic, Md. Khaledur Rahman, S. Cenk Sahinalp
Format: Artigo
Language:Inglês
Published: BMC 2019-07-01
Series:Algorithms for Molecular Biology
Subjects:
Intra-tumor heterogeneity
Tumor evolution
Multi-labeled tree
Tree edit distance
Dynamic programming
Online Access:http://link.springer.com/article/10.1186/s13015-019-0152-9
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