Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma

Abstract Background Accumulating evidences indicate that non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as crucial regulators in osteosarcoma (OS). Previously, we reported that Rho associated coiled-coil containing protein kinase 1 (ROCK1), a metastat...

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Hauptverfasser: Yong Wang, Xiandong Zeng, Ningning Wang, Wei Zhao, Xi Zhang, Songling Teng, Yueyan Zhang, Zhi Lu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-05-01
Schriftenreihe:Molecular Cancer
Schlagworte:
LncRNA DANCR
miR-335-5p/miR-1972
Osteosarcoma
Proliferation/Metastasis
ceRNA
Online Zugang:http://link.springer.com/article/10.1186/s12943-018-0837-6
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