The Beta3 499–513 Peptide Region is Required for AlphaIIb/ Beta3 Active Complex Formation and Fibrinogen Binding

Background: AlphaIIb/beta3 (αIIb/β3) complex is an important integrin that is involved in the final step of platelet aggregation. Peptides derived from either αIIb or β3 have demonstrated to have an effect on the activation of the complex and its ability to bind fibrinogen. We have previously defined a...

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Bibliographic Details
Main Authors: Virginia Woo-Rasberry, Thomas M. Chiang
Format: Artigo
Language:Inglês
Published: AboutScience Srl 2008-01-01
Series:Drug Target Insights
Subjects:
α2ß3 integrin
flow cytometry
disulphide bond
fibrinogen
integrin activation
mutagenesis
Online Access:http://la-press.com/article.php?article_id=755
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