Generation and characterization of a mitotane-resistant adrenocortical cell line

Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy. To investigate the underlying mechanisms in vitro, we here generated mitotane-resistant cell lines. After long-term pulsed treatment of HAC-1...

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Detalhes bibliográficos
Main Authors: Eric Seidel, Gudrun Walenda, Clemens Messerschmidt, Benedikt Obermayer, Mirko Peitzsch, Paal Wallace, Rohini Bahethi, Taekyeong Yoo, Murim Choi, Petra Schrade, Sebastian Bachmann, Gerhard Liebisch, Graeme Eisenhofer, Dieter Beule, Ute I Scholl
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica 2020-02-01
Colecção:Endocrine Connections
Assuntos:
chemotherapy
adrenolytic
somatic mutations
cholesterol
lipids
soat
Acesso em linha:https://ec.bioscientifica.com/view/journals/ec/9/2/EC-19-0510.xml
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