Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins. The method presented here describes the criticality assessment of therapeutic antibody modifications by size-exclusion chromatography (SEC) o...

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Detalhes bibliográficos
Main Authors: Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci, Pavel V. Bondarenko
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2021-01-01
Colecção:mAbs
Assuntos:
Monoclonal antibody
size exclusion chromatography
mass spectrometry
critical attribute assessment
competitive binding
antibody-antigen binding
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2021.1887612
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