Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out

Myofibroblasts are central mediators of fibrosis. Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally defined by acquired contractile function and high synthetic ability to produce extracellular matrix (ECM). Current literatu...

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Hlavní autoři: Joshua Zent, Lian-Wang Guo
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Edice:Cellular Physiology and Biochemistry
Témata:
Myofibroblast
Extracellular matrix
TGF-β1
EDA-FN
Positive feedback loop
On-line přístup:https://www.karger.com/Article/FullText/493217
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