Protein Arginine Methyltransferase 5 as a Therapeutic Target for <i>KRAS</i> Mutated Colorectal Cancer

Nearly 45% of colorectal cancer (CRC) patients harbor a mutation in their <i>KRAS</i> gene for which, despite many years of research, there are still no targeted therapies available. Protein Arginine Methyltransferase 5 (PRMT5) is a transcription regulator for multiple cellular processes...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: David Shifteh, Tzuriel Sapir, Moshe Pahmer, Adam Haimowitz, Sanjay Goel, Radhashree Maitra
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-07-01
Schriftenreihe:Cancers
Schlagworte:
CRC
PRMT5
<i>KRAS</i>
EPZ015666
Arginine methylation
Online Zugang:https://www.mdpi.com/2072-6694/12/8/2091
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