Alternative Splicing of NOX4 in the Failing Human Heart

Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. Therefore, we aimed to characterize NOX4 expression in human samples from hea...

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Main Authors: Zoltán V. Varga, Márton Pipicz, Júlia A. Baán, Tamás Baranyai, Gábor Koncsos, Przemyslaw Leszek, Mariusz Kuśmierczyk, Fátima Sánchez-Cabo, Pablo García-Pavía, Gábor J. Brenner, Zoltán Giricz, Tamás Csont, Luca Mendler, Enrique Lara-Pezzi, Pál Pacher, Péter Ferdinandy
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017-11-01
Serija:Frontiers in Physiology
Teme:
cardiomyopathy
oxidative stress
cardiac dysfunction
myocardium
aging
Online dostop:http://journal.frontiersin.org/article/10.3389/fphys.2017.00935/full
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