KnotAli: informed energy minimization through the use of evolutionary information

Abstract Background Improving the prediction of structures, especially those containing pseudoknots (structures with crossing base pairs) is an ongoing challenge. Homology-based methods utilize structural similarities within a family to predict the structure. However, their prediction is limited to...

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Hauptverfasser: Mateo Gray, Sean Chester, Hosna Jabbari
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-05-01
Schriftenreihe:BMC Bioinformatics
Schlagworte:
RNA secondary structure
MFE
Pseudoknot
Sequence alignment
Covariation
Thermodynamic energy minimization
Online Zugang:https://doi.org/10.1186/s12859-022-04673-3
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